Chronic inflammatory autoimmune respiratory conditions

Conditions

  • Asthma- Symptoms of an asthma attack include coughing, wheezing, shortness of breath, and chest tightness/pain/pressure.

Asthma is characterized by inflammation of the bronchial tubes with increased production of sticky secretions inside the tubes. People with asthma experience symptoms when the airways tighten, inflame, or fill with mucus. Some people with asthma may go for extended periods without having any symptoms, interrupted by periodic worsening of their symptoms called asthma attacks. Others might have asthma symptoms every day. In addition, some people may only have asthma during exercise, or asthma with viral infections like colds.Mild asthma attacks are generally more common. Usually, the airways open up within a few minutes to a few hours. Severe attacks are less common but last longer and require immediate medical help. It is important to recognize and treat even mild asthma symptoms to help you prevent severe episodes and keep asthma under better control.

  • CRSwNP- Symptoms of CRSwNP include nasal drainage, nasal congestion, facial pressure or pain, and a decreased sense of smell lasting for more than 12 weeks. Of these symptoms, nasal congestion and loss of smell tend to be the most bothersome.

Chronic rhinosinusitis (CRS) is one of the most common medical conditions worldwide, reported to affect almost 12% of the adult population. It is characterized by inflammation of the nose and sinus cavities. About 20% of patients with CRS have nasal polyps, benign growths in the nasal cavities that are thought to originate from the ethmoid sinuses. Nasal polyps tend to be present in both sides of the nasal cavity. One-sided nasal polyps may need to be investigated further as they might be malignant nasal or sinus tumors. The exact cause of chronic rhinosinusitis with nasal polyps (CRSwNP) is unknown but biopsy of nasal polyp tissue in the western population demonstrates an elevated allergic type of cells known as eosinophils. Infection may also play a role, especially by bacteria called Staphylococcus aureus. Typically, nasal polyps develop in adulthood in the 30s or 40s.

  • Sarcoidosis- Signs and symptoms of sarcoidosis vary depending on which organs are affected. Sarcoidosis sometimes develops gradually and produces symptoms that last for years. Other times, symptoms can appear suddenly and then disappear just as quickly. Many people with sarcoidosis have no symptoms. General symptoms can begin with fatigue, swollen lymph nodes, weight loss, and pain and swelling in joints such as the ankles.

Sarcoidosis is a disease characterized by the growth of tiny collections of inflammatory cells (granulomas) in any part of your body — most commonly the lungs and lymph nodes. But it can also affect the eyes, skin, heart and other organs. The cause of sarcoidosis is unknown, but experts think it results from the body's immune system responding to an unknown substance. Some research suggests that infectious agents, chemicals, dust and a potential abnormal reaction to the body's own proteins (self-proteins) could be responsible for the formation of granulomas in people who are genetically predisposed. There is no cure for sarcoidosis, but most people do very well with no treatment or only modest treatment. In some cases, sarcoidosis goes away on its own. However, sarcoidosis may last for years and may cause organ damage.

Medications

XOLAIR

XOLAIR is used to treat moderate to severe asthma in adults and children over 12 years of age. It works by blocking your immune system's natural response to allergic triggers that can lead to an acute asthma. This effect on your immune system helps keep your air passages open and, over time, it keeps your asthma in better control.

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HP ACTHAR GEL

HP Acthar Gel (corticotropin) is a prescription medication approved by the FDA for symptomatic sarcoidosis. Acthar works directly with your body to help produce its own natural steroid hormones. It is not a steroid.

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DUPIXENT

DUPIXENT is a prescription medicine used to treat people aged 12 years and older in combination with other medicines for the maintenance treatment of moderate-to-severe asthma whose asthma is not controlled with their current medicines. DUPIXENT helps prevent severe asthma attacks and can improve your breathing. Dupixent may also help reduce the amount of oral corticosteroids you need while preventing severe asthma attacks and improving your breathing. DUPIXENT is also used with other medicines for the maintenance treatment of chronic rhinosinusitis with nasal polyposis (CRSwNP) in adults whose disease is not controlled.

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FASENRA

FASENRA is a prescription medicine used with other asthma medicines for the maintenance treatment of asthma in people 12 years and older whose asthma is not controlled with their current asthma medicines. FASENRA helps prevent severe asthma attacks and may improve your breathing.

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NUCALA

NUCALA is a prescription medicine used with other medicines for add-on maintenance treatment of severe asthma in people 6 years of age and older whose asthma is not controlled with their current asthma medicines. NUCALA helps prevent severe asthma attacks.

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